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Some scientific anniversaries celebrate events so momentous that they capture the attention of many nonscientists as well — or even the entire world.

One such anniversary is upon us. December 2 marks the semisesquicentennial (75th anniversary) of the first controlled and sustained nuclear fission chain reaction. Only four years after German scientists discovered nuclear fission, scientists in America took the first step toward harnessing it. Many of those scientists were not Americans, though, but immigrants appalled by Hitler and horrified at the prospect that he might acquire a nuclear fission weapon.

Among the immigrants who initiated the American fission effort was Albert Einstein. His letter to President Franklin Roosevelt, composed at the request and with the aid of immigrant Leo Szilard from Hungary, warned of nuclear fission’s explosive potential. Presented with Einstein’s letter in October 1939, Roosevelt launched what soon became the Manhattan Project, which eventually produced the atomic bomb. It was another immigrant, Enrico Fermi from Italy, who led the initial efforts to show that building an atomic bomb was possible.

Fermi had arrived in the United States in January 1939, shortly after receiving the Nobel Prize in physics for his work on creating artificial elements heavier than uranium. Except that he hadn’t actually done so — his “new elements” were actually familiar elements produced by the splitting of the uranium nucleus. But nobody knew that fission was possible, so Fermi had misinterpreted his results. Chemists Otto Hahn and Fritz Strassmann, working in Germany, conducted experiments in 1938 that produced the element barium by bombarding uranium with neutrons. So Hahn and Strassmann got the credit for discovering fission, although they didn’t really know what they had done either. It was Lise Meitner, a former collaborator of Hahn’s who had recently left Germany to avoid Nazi anti-Semitism, who figured out that they had split the uranium nucleus.
Meitner’s nephew Otto Frisch revealed her insight to Niels Bohr, the world’s leading atomic physicist, just as he stepped aboard a ship for a visit to America. Upon arriving in the United States, Bohr informed Fermi and Princeton University physicist John Archibald Wheeler of Hahn’s experiment and Meitner’s explanation. Fermi immediately began further experimental work at Columbia University to investigate fission, as did Szilard, also at Columbia (and others in Europe); Bohr and Wheeler tackled the issue from the theoretical side.

Fermi and Szilard quickly succeeded in showing that a fission “chain reaction” was in principle possible: Neutrons emitted from fissioning uranium nuclei could induce more fission. By September, Bohr and Wheeler had produced a thorough theoretical analysis, explaining the physics underlying the fission process and identifying which isotope of uranium fissioned most readily. It was clear that the initial speculations about fission’s potential power had not been exaggerated.

“Almost immediately it occurred to many people around the world that this could be used to make power and that it could be used for nuclear explosives,” another immigrant who worked on the Manhattan Project, the German physicist Hans Bethe, told me during an interview in 1997. “Lots of people verified that indeed when uranium is bombarded by neutrons, slow neutrons in particular, a process occurs which releases tremendous amounts of energy.”
Bethe, working at Cornell University, did not immediately join the fission project — he thought building a bomb would take too long to matter for World War II. “I thought this had nothing to do with the war,” he said. “So I instead went into radar.”

Fermi, despite being an immigrant, was put in charge of constructing an “atomic pile” (nowadays nuclear reactor) to verify the chain reaction theory. He was, after all, widely acknowledged as the world’s leading nuclear experimentalist (and was no slouch as a theorist either); colleagues referred to him as “The Pope” because of his supposed infallibility. Construction of the pile began on a squash court under the stands of the University of Chicago’s football stadium. The goal was to demonstrate the ability to generate a chain reaction, in which any one fissioning nucleus would emit enough neutrons to trigger even more nuclei to fission.

“It became clear to Fermi almost immediately that in order to do this with natural uranium you had to slow down the neutrons,” Bethe said.

Fermi decided that the best material for slowing neutrons was graphite, the form of carbon commonly used as pencil lead. But in preliminary tests the graphite did not do the job as Fermi had anticipated. He reasoned that the graphite contained too many impurities to work effectively. So Szilard began searching for a company that could produce ultrapure graphite. He found one, Bethe recalled, that happily agreed to meet Fermi’s purity requirements — for double the usual graphite price.
Ultimately Fermi’s atomic pile succeeded, producing a sustained chain reaction on December 2, 1942. That success led to the establishment of the secret laboratory in Los Alamos, N.M., where physicists built the bombs that brought World War II to an end in 1945.

By then, Bethe had been persuaded to join the project. He arrived at Los Alamos in April 1943 and witnessed the first nuclear explosion, at Alamogordo, N.M., on July 16, 1945.

“I was among the people who looked at it from a 20-mile distance,” he said. “It was impressive.”

Historians frequently cite the report of J. Robert Oppenheimer, director of the Los Alamos project, who said that the explosion reminded him of a line from the Hindu Bhagavad Gita: “Now I am become Death, the destroyer of worlds.”

Bethe recalled a different response, from one of the military officials on the scene.

“One of the officers at the explosion said, ‘My god. Those longhairs have let it get away from them.’”

PHILADELPHIA — Protein-manufacturing factories within cells are picky about which widgets they construct, new research suggests. These ribosomes may not build all kinds of proteins, instead opting to craft only specialty products.

Some of that specialization may influence the course of embryo development, developmental biologist and geneticist Maria Barna of Stanford University School of Medicine and colleagues discovered. Barna reported the findings December 5 at the joint meeting of the American Society for Cell Biology and European Molecular Biology Organization.
Ribosomes, which are themselves made up of many proteins and RNAs, read genetic instructions copied from DNA into messenger RNAs. The ribosomes then translate those instructions into other proteins that build cells and carry out cellular functions. A typical mammalian cell may carry 10 million ribosomes. “The textbook view of ribosomes is that they are all the same,” Barna said. Even many cell biologists have paid little attention to the structures, viewing them as “backstage players in controlling the genetic code.”

But that view may soon change. Ribosomes actually come in many varieties, incorporating different proteins, Barna and colleagues found. Each variety of ribosome may be responsible for reading a subset of messenger RNAs, recent studies suggest. For instance, ribosomes containing the ribosomal protein RPS25 build all of the proteins involved in processing vitamin B12, Barna and colleagues reported July 6 in Molecular Cell. Vitamin B12 helps red blood cells and nerves work properly, among other functions. Perhaps other biological processes are also controlled, in part, by having specific types of ribosomes build particular proteins, Barna said.

In unpublished work presented at the meeting, Barna and colleagues also found that certain ribosome varieties may be important at different stages of embryonic development. The researchers coaxed embryonic stem cells growing in lab dishes to develop into many types of cells. The team then examined the ribosomal proteins found in each type of cell. Of the 80 ribosomal proteins examined, 31 changed protein levels in at least one cell type, Barna said. The finding may indicate that specialized ribosomes help set a cell’s identity.

Although Barna’s idea of diverse ribosomes goes against the classical textbook view, “the concept is not heretical at all,” says Vassie Ware, a molecular cell biologist at Lehigh University in Bethlehem, Pa., not involved in the work.
These findings may help explain why some people with mutations in certain ribosomal protein genes develop conditions such as Diamond-Blackfan anemia — a blood disorder in which the bone marrow doesn’t make enough red blood cells — but don’t have problems in other body tissues, Ware says.

That disease is caused by mutations in the RPL5 and RPL11 genes, which encode ribosomal building blocks. If all ribosomes were alike, people with mutations in ribosomal components should have malfunctions all over their bodies, or might not ever be born. RPL5 and RPL11 proteins may be part of specialized ribosomes that are important in the bone marrow but not elsewhere in the body.

Despite their name, pelican spiders aren’t massive, fish-eating monstrosities. In fact, the shy spiders in the family Archaeidae are as long as a grain of rice and are a threat only to other spiders.

Discovering a new species of these tiny Madagascar spiders is tough, but Hannah Wood has done just that — 18 times over.

Wood, an arachnologist at the Smithsonian National Museum of Natural History in Washington D.C., analyzed the genes and anatomy of live and museum pelican spider specimens to find these new species. She describes them in a paper published online January 11 in ZooKeys.
Like other pelican spiders, the new species have an elongated “neck” and beaklike pincers, or chelicerae. The way they use those long chelicerae to strike from a distance, earned them another name: assassin spiders. Once impaled, the helpless prey dangles from these meat hooks until the venom does its work (SN: 3/22/14, p. 4).

Probing the spiders’ tiny anatomy under a microscope, Wood looked for hints to distinguish one species from another. Arachnologists often look to spiders’ genitals: Males and females from the same species typically evolved specially shaped organs to mate. If the “lock” doesn’t fit the “key,” the spiders are likely of a different species.

Thanks to Wood, 18 more species of pelican spiders — some of which were previously misclassified — now have names. Eriauchenius rafohy honors an ancient Madagascar queen, and E. wunderlichi, an eminent arachanologist. Wood, one of the foremost experts on pelican spiders, says she expects there are still more species to find. Perhaps an E. woodi?

A teenage girl climbed into an underground cave around 13,000 years ago. Edging through the ink-dark chamber, she accidentally plunged to her death at the bottom of a deep pit.

Rising seas eventually inundated the cave, located on Central America’s Yucatán Peninsula. But that didn’t stop scuba divers from finding and retrieving much of the girl’s skeleton in 2007.

“First Face of America,” a new NOVA documentary airing February 7 on PBS, provides a closeup look at two dangerous underwater expeditions that resulted in the discovery and salvaging of bones from one of the earliest known New World residents, dubbed Naia.
The program describes how studies of Naia’s bones (SN: 6/14/14, p. 6) and of genes from an 11,500-year-old infant recently excavated in Alaska have generated fresh insights into how people populated the Americas. Viewers watch anthropologist and forensic consultant James Chatters, who directed scientific studies of Naia’s remains, as he reconstructs the ancient teen’s face and charts the lower-body injuries that testify to what must have been a rough life.
In one suspenseful scene, cameras record Chatters talking with scuba divers shortly before the divers descend into the submerged cave to collect Naia’s bones. The scientist describes how thousands of years of soaking in seawater have rendered the precious remains fragile. He uses a plaster cast of a human jaw to demonstrate for scuba diver Susan Bird how to handle Naia’s skull so that it stays intact while being placed in a padded box. Bird’s worried expression speaks volumes.

“On the day of the dive, there was so much tension, so many people on the verge of freaking out,” Bird recalls in the show. When the divers return from their successful mission, collective joy breaks out.
The scene then shifts to a lab where Chatters painstakingly re-creates what Naia looked like. Asian-looking facial features raise questions about how the ancient youth ended up in Central America. That’s where University of Alaska Fairbanks anthropologist Ben Potter enters the story. In 2013, Potter and colleagues excavated the remains of two infant girls at an Alaskan site dating nearly to Naia’s time. Analysis of DNA recovered from one of the infants , described in the Jan. 11 Nature , supports a scenario in which a single founding Native American population reached a land bridge that connected northeast Asia to North America around 35,000 years ago. As early as 20,000 years ago, those people had moved into their new continent, North America. Naia’s face reflects her ancestors’ Asian roots.
In tracing back how people ended up in the Americas, NOVA presents an outdated model of ancient humans moving out of Africa along a single path through the Middle East around 80,000 years ago. Evidence increasingly indicates that people started leaving Africa 100,000 years ago or more via multiple paths (SN: 12/24/16, p. 25). That’s a topic for another show, though. In this one, Naia reveals secrets about the peopling of the Americas with a lot of help from intrepid scuba divers and state-of-the-art analyses. It’s fitting that a slight smile creases her reconstructed face.

One of the strangest things about growing a human being inside your body is the alien sensation of his movements. It’s wild to realize that these internal jabs and pushes are the work of someone else’s nervous system, skeleton and muscles. Someone with his own distinct, mysterious agenda that often includes taekwondoing your uterus as you try to sleep.

Around the 10-week mark, babies start to bend their heads and necks, followed by full-body wiggles, limb movement and breathing around 15 weeks. These earliest movements are usually undetectable by pregnant women, particularly first-timers who may not recognize the flutters until 16 to 25 weeks of pregnancy. These movements can be exciting and bizarre, not to mention uncomfortable. But for the developing baby, these kicks are really important, helping to sculpt muscles, bones and joints.
While pregnant women can certainly sense a jab, scientists have largely been left in the dark about how normal fetuses move. “It’s extremely difficult to investigate fetal movements in detail in humans,” says Stefaan Verbruggen, a bioengineer formerly at Imperial College London who recently moved to Columbia University in New York.

Now, using relatively new MRI measurements of entire fetuses wiggling in utero, researchers have tracked these kicks across women’s pregnancies. The results, published January 24 in the Journal of the Royal Society Interface, offer the clearest look yet at fetal kicking and provide hints about why these moves are so important.
Along with bioengineer Niamh Nowlan, of ICL, and colleagues, Verbruggen analyzed videos of fetal kicks caught on MRI scans. These scans, from multiple pregnant women, included clear leg kicks at 20, 25, 30 and 35 weeks gestation. Other MRI scans provided anatomical details about bones, joints and leg sizes. With sophisticated math and computational models, the researchers could estimate the strengths of the kicks, as well as the mechanical effects, such as stresses and strains, that those kicks put on fetal bones and joints.
Kicks ramped up and became more forceful from 20 to 30 weeks, the researchers found. During this time, kicks shifted the wall of the uterus by about 11 millimeters on average, the team found. But by 35 weeks, kick force had declined, and the uterus moved less with each kick, only about 4 millimeters on average. (By this stage, things are getting pretty tight and tissues might be stretched taut, so this decrease makes sense.) Yet even with this apparent drop in force, the stresses experienced by the fetus during kicks kept increasing, even until 35 weeks. Increasing pressure on the leg bones and joints probably help the fetus grow, the researchers write.

Other work has found that the mechanical effects of movement can stimulate bone growth, which is why weight-bearing exercises, such as brisk walking and step aerobics, are often recommended for people with osteoporosis. In animal studies, stationary chick and mouse fetuses have abnormal bones and joints, suggesting that movement is crucial to proper development.

The results highlight the importance of the right kinds of movements for fetuses’ growth. Babies born prematurely can sometimes have joint disorders. It’s possible that bone growth and joints are affected when babies finish developing in an environment dominated by gravity, instead of the springy, tight confines of a uterus. Even in utero position might have an effect. Head-up breech babies, for instance, have a higher risk of a certain hip disorder, a link that hints at a relationship between an altered kicking ground and development. In fact, the researchers are now looking at the relationship between fetal movements and skeletal stress and strain in these select groups.

Mechanical forces in utero might have long-lasting repercussions. Abnormal joint shapes are thought to increase the risk of osteoarthritis, says Verbruggen, “which means that how you move in the womb before you’re even born can affect your health much later in life.”

There’s a lot more work to do before scientists fully understand the effects of fetal movements, especially those in less than ideal circumstances. But by putting hard numbers to squirmy wiggles, this new study is kicking things off right.

It’s another record for SpaceX. At 3:50 p.m. Eastern on February 6, the private spaceflight company launched the Falcon Heavy rocket for the first time.

The Heavy — essentially three SpaceX Falcon 9 rocket boosters strapped together — is the most powerful rocket launched since the Saturn V, which shot astronauts to the moon during the Apollo program. SpaceX hopes to use the Heavy to send humans into space. The company is developing another rocket, dubbed the BFR, to eventually send people to Mars.
Another first for this launch: the synchronized return of two of the boosters. (The third, from the center core, didn’t descend properly, and instead of landing on a droneship, it hit the ocean at 300 mph.) Part of SpaceX’s program is to reuse rockets, which brings down the cost of space launches. The company has successfully landed the cores of its Falcon 9 rockets 21 times and reflew a rocket six times. The company landed a previously used rocket for the first time in March.

But the cargo for today’s launch is aimed at another planet. The rocket carried SpaceX CEO Elon Musk’s red Tesla Roadster with “Space Oddity” by David Bowie playing on the stereo. It is now heading toward Mars.

“I love the thought of a car drifting apparently endlessly through space and perhaps being discovered by an alien race millions of years in the future,” Musk tweeted in December.
Editor’s note: This story was updated on February 7 to update the status of the booster landings, and again on February 9 to correct the rocket that SpaceX hopes to use to send people to Mars. The company intends to use its BFR rocket, not the Falcon Heavy.

Bedbugs leave a lasting legacy.

Their poop contains a chemical called histamine, part of the suite of pheromones that the insects excrete to attract others of their kind. Human exposure to histamine can trigger allergy symptoms like itchiness and asthma. (Our bodies also naturally release histamine when confronted with an allergen.) Histamine stays behind long after the bedbugs disappear, scientists report February 12 in PLOS ONE.

Researchers from North Carolina State University in Raleigh collected dust from apartments in a building with a chronic bedbug infestation. After a pest control company treated the apartments by raising the temperature to a toasty 50° Celsius, the researchers sampled the dust again. They compared those two sample groups with a third, from area homes that hadn’t had bedbugs for at least three years.

Dust from the infested apartments had levels of histamine chemical that were 22 times as much as the low amount found in bedbug-free houses, the researchers found. And while the heat treatment got rid of the tiny bloodsuckers, it didn’t lower the histamine levels.

Future pest control treatments might need to account for bedbugs’ long-term effects.

AUSTIN, Texas — An analysis of the metals in dozens of Picasso’s bronze sculptures has traced the birthplace of a handful of the works of art to the outskirts of German-occupied Paris during World War II.

This is the first time that the raw materials of Picasso’s sculptures have been scrutinized in detail, conservation scientist Francesca Casadio of the Art Institute of Chicago said February 17 at the annual meeting of the American Association for the Advancement of Science. And the elemental “fingerprints” help solve a mystery surrounding the sculptures’ origins.
“In collaboration with curators, we can write a richer history of art that is enriched by scientific findings,” Casadio said.

Casadio and colleagues from the Art Institute of Chicago and Northwestern University in Evanston, Ill., studied 39 bronzes in the collection of the Picasso Museum in Paris. The team used a portable X-ray fluorescence spectrometer to record the amount of copper, tin, zinc and lead at several points on each sculpture.
Based on the percentage of tin versus zinc in the bronze, “we found that there are compositional groups that relate to a specific foundry,” Casadio said. Seventeen sculptures had a foundry mark on them, so the researchers could relate metal mixes to specific foundries.
But seven sculptures lack foundry marks. Based on their composition, researchers pegged five to a specific foundry — that of Émile Robecchi, a craftsman whose workshop sat in the southern outskirts of Paris. Original invoices from the foundry surfaced two years ago and revealed when some of the pieces were cast. For instance, the description, weight and size written on one invoice confirmed that the bronze of Tête de femme de profil (Marie­Thérèse) — a portrait of one of Picasso’s mistresses originally sculpted in plaster in 1931 — was cast at the foundry in February 1941.
At that time, the war had been under way for years and the Germans had just occupied Paris. Picasso worried that his fragile plaster sculptures could be easily destroyed and sought to have them cast in bronze.

The team’s analysis also found two distinct mixtures of bronze that came out of the Robbechi foundry. That difference makes sense in the context of 1940s occupied Paris, when the Germans instituted laws requiring that people turn in certain metals to go toward war efforts, Casadio said.

“A lot of [foundries’] archives are incomplete or nonexistent,” Casadio said. The new analysis “reinforces why it’s really important to collaborate and how science adds the missing piece of the puzzle.”

Chile’s Atacama Desert is so dry that some spots see rain only once a decade. Salt turns the sandy soil inhospitable, and ultraviolet radiation scorches the surface. So little can survive there that scientists have wondered whether snippets of DNA found in the soil are just part of the desiccated skeletons of long-dead microbes or traces of hunkered-down but still living colonies.

A rare deluge has solved that mystery. Storms that dumped a few centimeters of rain on the Atacama in March 2015 — a decade’s worth in one day — sparked a microbial superbloom, researchers report February 26 in Proceedings of the National Academy of Sciences.
That storm initially threw a wrench into plans for scientists to get a snapshot of microbial life under normal, hyperarid conditions in the Atacama. “But in the end, it came back as a lucky stroke,” says study coauthor Dirk Schulze-Makuch, an astrobiologist at the Technische Universität Berlin. He and his colleagues drove mining vehicles into the desert to collect soil samples just a few weeks after the storm, and then returned again in 2016 and 2017 to track changes as the moisture dissipated.

The team found microbes — a mix of extremophile archaea, bacteria and fungi — that were tolerant of desiccation, salinity and UV radiation. The kinds of species were fairly consistent across sampling sites, which suggests there’s something of a native microbial community that can survive in this salty sand by going dormant between periods of moisture, says Schulze-Makuch.

Schulze-Makuch and his colleagues also found evidence for enzymes that are by-products of cellular metabolism. And traces of ATP, the molecule that cells use for energy, lingered inside cells. Those markers of life were the most bountiful at the first sampling time, and then declined as the soil dried out again.

Collectively, it’s evidence that microbes aren’t just dying and leaving their DNA behind in the Atacama — they’re laying low to live another day. That’s encouraging to Schulze-Makuch: He’s interested in the Atacama as a proxy for conditions on Mars.
Armando Azua-Bustos, an astrobiologist at the Centro de Astrobiología in Madrid who was not part of this study, agrees. “If we’re finding that, on Earth, truly dry places are still inhabited,” he says. “That opens the door to finding life elsewhere in the universe.”

LOS ANGELES — Quantum computers are bulking up.

Researchers from Google are testing a quantum computer with 72 quantum bits, or qubits, scientists reported March 5 at a meeting of the American Physical Society — a big step up from the company’s previous nine-qubit chip.

The team hopes to use the larger quantum chip to demonstrate quantum supremacy for the first time, performing a calculation that is impossible with traditional computers (SN: 7/8/17, p. 28), Google physicist Julian Kelly reported.
Achieving quantum supremacy requires a computer of more than 50 qubits, but scientists are still struggling to control so many finicky quantum entities at once. Unlike standard bits that take on a value of 0 or 1, a qubit can be 0, 1 or a mashup of the two, thanks to a quantum quirk known as superposition.

Nicknamed Bristlecone because its qubits are arranged in a pattern resembling a pinecone’s scales, the computer is now being put through its paces. “We’re just starting testing,” says physicist John Martinis of Google and the University of California, Santa Barbara. “From what we know so far, we’re very optimistic.” The quantum supremacy demonstration could come within a few months if everything works well, Martinis says.

Google is one of several companies working to make quantum computers a reality. IBM announced it was testing a 50-qubit quantum computer in November 2017 (SN Online: 11/10/17), and Intel announced a 49-qubit test chip in January.